Cardiac gene expression profiling may reveal key differences between physiologic and pathologic cardiac hypertrophy
نویسندگان
چکیده
منابع مشابه
Genetic Expression Profiles During Physiologic and Pathologic Cardiac Hypertrophy and Heart Failure in Rats
Cardiac hypertrophy is a complex and non-homogenous response to various stimuli. In this study, we used high-density oligonucleotide microarray to examine gene expression profiles during physiologic hypertrophy, pathologic hypertrophy, and heart failure in Dahl salt-sensitive rats. There were changes in 404/3160 and 874/3160 genes between physiologic vs. pathologic hypertrophy and the transitio...
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In the present study we determined the long-term effects of persistent, local insulin-like growth factor I (IGF-I) expression on cardiac function in the SIS2 transgenic mouse. Cardiac mass/tibial length was increased in SIS2 mice by 10 wk of age; this cardiac hypertrophy became more pronounced later in life. Peak aortic outflow velocity, a correlate of cardiac output, was increased at 10 wk in ...
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To evaluate the combined effects of cardiac overload imposed by hypertension and by chronic exercise, male and female rats were made hypertensive by unilateral renal artery stenoses and made to exercise in an 8-10-wk swimming program. Sedentary normotensive animals, sedentary hypertensive animals and normotensive animals exposed to the swimming program were also studied. Hypertension was associ...
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How obesity or sex may affect the gene expression profiles of human cardiac hypertrophy is unknown. We hypothesized that body-mass index (BMI) and sex can affect gene expression profiles of cardiac hypertrophy. Human heart tissues were grouped according to sex (male, female), BMI (lean<25 kg/m2, obese>30 kg/m2), or left ventricular hypertrophy (LVH) and non-LVH nonfailed controls (NF). We ident...
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ژورنال
عنوان ژورنال: Acta Physiologica Scandinavica
سال: 2005
ISSN: 0001-6772
DOI: 10.1111/j.1365-201x.2005.01500_1.x